منابع مشابه
Transdermal delivery of testosterone.
Male hypogonadism has been treated with exogenous testosterone since the 1930s. The early transdermal patches of testosterone became available in the 1980s with gel and solution preparations following subsequent decades. This review focusses on the skin permeation characteristics of testosterone, pharmacokinetics following application of transdermal formulations and formulations currently avail...
متن کاملMicroemulsion formulations for the transdermal delivery of testosterone.
The objective was to develop a microemulsion formulation for the transdermal delivery of testosterone. Microemulsion formulations were prepared using oleic acid as the oil phase, Tween20 as a surfactant, Transcutol as cosurfactant, and water. The microemulsions were characterized visually, with the polarizing microscope, and by dynamic light scattering. In addition, the pH, conductivity (sigma)...
متن کاملPharmacokinetics of a new testosterone transdermal delivery system, TDS
Results The mean AUC(0,12 h) was higher following application of TDS ® -testosterone (61.8 ng ml − 1 h), compared with Androgel ® (57.7 ng ml − 1 h) and TDS ® -placebo (50.7 ng ml − 1 h. The mean C max (0,12 h) was similar for TDS ® -testosterone (6.6 ng ml −1 ) and Androgel ® (6.5 ng ml − 1 ) and these values were higher than those for TDS ® -placebo (5.7 ng ml − 1 ). Analysis of variance show...
متن کاملPharmacokinetics of a new testosterone transdermal delivery system, TDS-testosterone in healthy males.
AIMS The Transdermal Delivery System (TDS) is a liquid formulation that can be applied to the skin via a metered pump spray to deliver drug to the systemic circulation. The aims of this study were to assess the ability of the TDS preparation to deliver testosterone systemically, and to characterize the pharmacokinetic profiles of the hormone in healthy males. METHODS An open label, comparativ...
متن کاملNovel transdermal drug delivery systems
Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Meth...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics
سال: 2015
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2015.02.015